Long-term outcome in children with Hodgkin's lymphoma: the United Kingdom Children's Cancer Study Group HD82 trial

Eur J Cancer. 2007 May;43(7):1171-9. doi: 10.1016/j.ejca.2007.01.023. Epub 2007 Mar 26.


Background: The aim of United Kingdom Children's Cancer Study Group (UKCCSG) HD82 was to establish the efficacy of chlorambucil/vinblastine/procarbazine/prednisolone (ChlVPP) in the treatment of childhood Hodgkin's lymphoma stages II-IV and radiotherapy (RT) alone in stage I patients. We report on the status of these patients to a follow-up of 20 years.

Methods: Treatment consisted of 35Gy involved-field RT for stage I and ChlVPP alone for stages II-IV. Adjuvant RT (35Gy) was administered to those with bulky mediastinal disease.

Results: Of the 358 patients, the 10-year EFS/OS per stage is I (65.4%/92.6%), II (80.0%/93.3%), III (68.8%/85.0%), IV (45.5%/72.7%). The corresponding 20-year OS rates are similar with a combined (all stage) rate dropping from 89.3% to 89.0% over the decade. The cumulative 20-year malignancy rate is 7.29%.

Conclusion: Single modality treatment provided relatively low EFS at 10-years but comparable long-term OS, relative to contemporary published combined modality regimens, for stages I-III but not for stage IV patients.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Child
  • Child, Preschool
  • Chlorambucil / administration & dosage
  • Disease-Free Survival
  • Follow-Up Studies
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / mortality
  • Hodgkin Disease / radiotherapy
  • Humans
  • Infant
  • Infant, Newborn
  • Neoplasm Recurrence, Local / mortality
  • Neoplasms, Second Primary / mortality
  • Prednisolone / administration & dosage
  • Procarbazine / administration & dosage
  • Radiotherapy, Adjuvant
  • Treatment Outcome
  • Vinblastine / administration & dosage


  • Chlorambucil
  • Procarbazine
  • Vinblastine
  • Prednisolone

Supplementary concepts

  • ChlVPP protocol