In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits

J Ethnopharmacol. 2007 Jun 13;112(2):394-400. doi: 10.1016/j.jep.2007.03.029. Epub 2007 Mar 30.


The aqueous and ethanol extracts of Rosa canina L. (Rosaceae) fruits and the fractions prepared from the latter were investigated for their anti-inflammatory and antinociceptive activities in several in vivo experimental models. The ethanolic extract was shown to possess significant inhibitory activity against inflammatory models (i.e., carrageenan-induced and PGE(1)-induced hind paw edema models, as well as on acetic acid-induced increase in a capillary permeability model) and on a pain model based on the inhibition of p-benzoquinone-induced writhing in mice. Hexane, chloroform, ethylacetate, n-butanol and the remaining water fractions were obtained through bioassay-guided fractionation. Ethylacetate and n-butanol fractions displayed potent anti-inflammatory and antinociceptive activities at a dose of 919 mg/kg without inducing acute toxicity. Further attempts to isolate and define the active constituent(s) were inconclusive, possibly due to the synergistic interaction of components in the extract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alprostadil
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Benzoquinones
  • Capillary Permeability / drug effects
  • Carrageenan
  • Edema / chemically induced
  • Edema / pathology
  • Edema / prevention & control
  • Ethanol
  • Foot / pathology
  • Fruit / chemistry
  • Male
  • Mice
  • Pain Measurement / drug effects
  • Plant Extracts / pharmacology
  • Plant Extracts / toxicity
  • Rosa / chemistry*
  • Rosa / toxicity
  • Solvents
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / pathology
  • Tetradecanoylphorbol Acetate


  • Analgesics
  • Anti-Inflammatory Agents
  • Benzoquinones
  • Plant Extracts
  • Solvents
  • Ethanol
  • quinone
  • Carrageenan
  • Alprostadil
  • Tetradecanoylphorbol Acetate