Hodgkin's lymphoma in children aged 5 years or less - the United Kingdom experience

Eur J Cancer. 2007 Jun;43(9):1415-21. doi: 10.1016/j.ejca.2007.03.013. Epub 2007 May 16.


Purpose: The aim of this study is to describe the natural history of Hodgkin's Lymphoma (HL) in a large unselected group of children aged 5 years or below at diagnosis, who were treated on a standard treatment programme in the United Kingdom between 1982 and 2000.

Methods: Eighty-one unselected children with HL aged 5 years or under at diagnosis, treated on the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's trials HD1 (1982-1992) and HD2 (1992-2000), were included in the study.

Results: Sixty-one patients (81%) presented with early stage disease (n=66). Fifty-three patients (65%) received combination chemotherapy, 28 (34%) received involved field radiotherapy (IF-RT) and 4 patients were treated with combined modality therapy. Eighteen children relapsed after primary therapy.

Conclusions: Children treated with IF-RT had a higher rate of primary treatment failures as well as increased late treatment-related morbidity.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Combined Modality Therapy / mortality
  • Disease-Free Survival
  • Female
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / mortality*
  • Hodgkin Disease / radiotherapy
  • Humans
  • Male
  • Neoplasm Recurrence, Local
  • Radiotherapy / adverse effects
  • Treatment Failure
  • United Kingdom