The hard cell: from proteomics to a whole cell model

FEBS Lett. 2007 Jun 19;581(15):2870-6. doi: 10.1016/j.febslet.2007.05.062. Epub 2007 May 30.


Proteomics has provided a wealth of data related to the nature of the proteome, including subcellular location, copy number, interaction partners and protein complexes. This raises the question of whether it is feasible to combine these data, together with other data related to overall cellular structure, to construct a static picture of the cell. In this minireview, we discuss these data, and the issues of turning them into whole cell models.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cells / metabolism*
  • Genomics
  • Humans
  • Models, Biological*
  • Multiprotein Complexes
  • Proteomics*
  • Two-Hybrid System Techniques


  • Multiprotein Complexes