Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial

Int J Impot Res. Mar-Apr 2008;20(2):173-80. doi: 10.1038/sj.ijir.3901597. Epub 2007 Aug 16.

Abstract

In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine / pharmacology
  • Arginine / therapeutic use*
  • Aspartic Acid / pharmacology
  • Aspartic Acid / therapeutic use*
  • Blood Pressure / drug effects
  • Cholesterol / blood
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Combinations
  • Drug Therapy, Combination
  • Erectile Dysfunction / drug therapy*
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Neurotransmitter Agents / pharmacology
  • Neurotransmitter Agents / therapeutic use*
  • Nitric Oxide Synthase / metabolism
  • Penile Erection
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Testosterone / blood*
  • Treatment Outcome
  • Vasodilator Agents / pharmacology
  • Vasodilator Agents / therapeutic use*

Substances

  • Drug Combinations
  • Flavonoids
  • Neurotransmitter Agents
  • Plant Extracts
  • Vasodilator Agents
  • prelox
  • Aspartic Acid
  • Testosterone
  • pycnogenols
  • Arginine
  • Cholesterol
  • Nitric Oxide Synthase
  • arginine aspartate