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Randomized Controlled Trial
. Mar-Apr 2008;20(2):173-80.
doi: 10.1038/sj.ijir.3901597. Epub 2007 Aug 16.

Improvement of Erectile Function With Prelox: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

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Randomized Controlled Trial

Improvement of Erectile Function With Prelox: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

R Stanislavov et al. Int J Impot Res. .

Abstract

In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.

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