Atopic dermatitis: an update and review of the literature

Dermatol Clin. 2007 Oct;25(4):605-12, x. doi: 10.1016/j.det.2007.06.009.


Atopic eczema/dermatitis from the aspects of immunologic background, genetics, skin barrier dysfunction, IgE receptors, and triggers of AD (including allergens, microorganisms, and autoantigens) is described. Also reviewed are diagnostic procedures, treatment modalities with topical treatment (emollients, topical corticosteroids, topical calcineurin inhibitors, wet wrap therapy, and topical antimicrobial therapy), systemic management (antimicrobials, systemic corticosteroids, cyclosporine A, azathioprine, antihistamines), and phototherapy. Primary and secondary prevention are discussed and the role of the different cell receptors and their up-and down-regulation in this setting are emphasized.

Publication types

  • Review

MeSH terms

  • Cytokines / immunology
  • Dermatitis, Atopic* / diagnosis
  • Dermatitis, Atopic* / drug therapy
  • Dermatitis, Atopic* / immunology
  • Dermatitis, Atopic* / therapy
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Immunoglobulin E / immunology
  • Immunologic Factors / therapeutic use*
  • Patch Tests
  • Receptors, IgE / immunology
  • Skin / immunology
  • Skin / physiopathology*
  • T-Lymphocytes / physiology


  • Cytokines
  • Dermatologic Agents
  • Immunologic Factors
  • Receptors, IgE
  • Immunoglobulin E