Perisomatic inhibition

Neuron. 2007 Oct 4;56(1):33-42. doi: 10.1016/j.neuron.2007.09.012.


Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anxiety / pathology
  • Anxiety / physiopathology
  • Cerebral Cortex / cytology*
  • Cholecystokinin / metabolism
  • Epilepsy / pathology
  • Epilepsy / physiopathology
  • Humans
  • Models, Neurological
  • Nerve Net / physiology*
  • Neural Inhibition / physiology*
  • Neurons / classification
  • Neurons / physiology
  • Parvalbumins / metabolism


  • Parvalbumins
  • Cholecystokinin