Heterocyst patterns without patterning proteins in cyanobacterial filaments

Dev Biol. 2007 Dec 1;312(1):427-34. doi: 10.1016/j.ydbio.2007.09.045. Epub 2007 Sep 29.

Abstract

We have quantitatively modeled heterocyst differentiation after fixed nitrogen step-down in the filamentous cyanobacterium Anabaena sp. PCC 7120 without lateral inhibition due to the patterning proteins PatS or HetN. We use cell growth and division together with fixed-nitrogen dynamics and allow heterocysts to differentiate upon the local exhaustion of available fixed nitrogen. Slow transport of fixed nitrogen along a shared periplasmic space allows for fast growing cells to differentiate ahead of their neighbors. Cell-to-cell variability in growth rate determines the initial heterocyst pattern. Early release of fixed nitrogen from committed heterocysts allows a significant fraction of vegetative cells to be retained at later times. We recover the experimental heterocyst spacing distributions and cluster size distributions of Khudyakov and Golden [Khudyakov, I.Y., Golden, J.W., 2004. Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp PCC 7120, can be separated by mutation. Proc. Natl. Acad. Sci. U. S. A. 101, 16040-16045].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anabaena / cytology*
  • Anabaena / growth & development*
  • Bacterial Proteins / metabolism*
  • Cell Division
  • Models, Biological
  • Nitrogen Fixation
  • Time Factors

Substances

  • Bacterial Proteins