Glioblastoma multiforme: the role of DSB repair between genotype and phenotype

Oncogene. 2007 Dec 10;26(56):7809-15. doi: 10.1038/sj.onc.1210878.


Glioblastoma is the most frequent primary brain tumor in adults. The average survival time of less than 1 year did not improve notably over the last three decades. The dismal prognosis of glioblastoma patients is largely due to the striking radioresistance of this tumor. Here, we attempt a combined view on the genetics, the repair mechanisms and the radioresistance of glioblastoma. Specifically, we address the role of DNA-PKcs and the novel potential end-joining factor KUB3 in maintaining the radioresistant phenotype, the interrelationship between genetic lesions and repair mechanisms, and new perspectives that emerge from the identification of glioblastoma stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / genetics*
  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • DNA, Neoplasm / genetics*
  • Genotype
  • Glioblastoma / genetics*
  • Humans
  • Phenotype


  • DNA, Neoplasm