Toxic epidermal necrolysis and fluoxetine: a case report

J Clin Psychopharmacol. 2008 Feb;28(1):93-5. doi: 10.1097/jcp.0b013e3181604015.


Toxic epidermal necrolysis (TEN) is a distinct clinical entity within a spectrum of adverse cutaneous drug reactions. It is characterized by >30% of the body surface area of skin detachment with an average reported mortality of 25-35%. Drug induced TEN is associated with various antibiotics, anticonvulsants and other drugs. While adverse cutaneous drug reactions are common with antidepressants, the majority eruptions are benign and easily treated. TEN is rarely reported in association with selective serotonin reuptake inhibitors (SSRI's). We describe TEN in a 34-year-old patient from Mozambique associated with the addition of fluoxetine for a major depressive episode with psychotic features.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / adverse effects*
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Depressive Disorder, Major / drug therapy
  • Female
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Humans
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Stevens-Johnson Syndrome / etiology*


  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Fluoxetine