Consumptive coagulopathy associated with Gorham syndrome and subsequent Kasabach-Merritt syndrome during pregnancy: a case report

J Reprod Med. 2007 Dec;52(12):1103-6.


Background: Gorham and Kasabach-Merritt syndrome are rare diagnoses that can complicate pregnancy by increasing the risk of pelvic fracture and consumptive coagulopathy, respectively.

Case: A 23-year-old woman, gravida 2, para 0101, with a prenatal diagnosis of Gorham syndrome from her previous pregnancy was admitted at 32 weeks' gestation with severe back and flank pain. Computed tomographic findings revealed multiple lytic lesions of the pelvis in addition to large hemangiomas. Similar to her first pregnancy, she quickly developed consumptive coagulopathy and required prompt preterm delivery. The postoperative course was complicated by prolonged intensive care and multiple transfusions.

Conclusion: The consumptive coagulopathy associated with Gorham syndrome and secondary Kasabach-Merritt syndrome can mimic severe preeclampsia, especially when recurrent.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms / complications*
  • Bone Neoplasms / diagnosis
  • Cesarean Section
  • Disseminated Intravascular Coagulation / complications*
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / therapy
  • Erythrocyte Transfusion
  • Female
  • Hemangioma, Cavernous / complications*
  • Hemangioma, Cavernous / diagnosis
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Osteolysis, Essential / complications*
  • Pelvic Neoplasms / complications*
  • Pelvic Neoplasms / diagnosis
  • Pregnancy
  • Pregnancy Complications, Hematologic / diagnosis*
  • Pregnancy Complications, Hematologic / therapy
  • Syndrome
  • Treatment Outcome