The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study

Lipids Health Dis. 2008 Mar 31;7:12. doi: 10.1186/1476-511X-7-12.

Abstract

Aim: To evaluate the effects of two formulations, Cissus quadrangularis-only and a Cissus quadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects.

Methods: The study was a 10 week randomized, double-blind, placebo-controlled design involving 72 obese or overweight participants (45.8% male; 54.2% female; ages 21-44; mean age = 29.3). The participants were randomly divided into three equal (n = 24) groups: placebo, Cissus quadrangularis-only, and Cissus quadrangularis/Irvingia gabonensis combination. Capsules containing the placebo or active formulations were administered twice daily before meals; no major dietary changes nor exercises were suggested during the study. A total of six anthropomorphic and serological measurements (body weight, body fat, waist size; total plasma cholesterol, LDL cholesterol, fasting blood glucose level) were taken at baseline and at 4, 8 and 10 weeks.

Results: Compared to the placebo group, the two active groups showed a statistically significant difference on all six variables by week 10. The magnitude of the differences was noticeable by week 4 and continued to increase over the trial period.

Conclusion: Although the Cissus quadrangularis-only group showed significant reductions on all variables compared to the placebo group, the Cissus quadrangularis/Irvingia gabonensis combination resulted in even larger reductions. This apparently synergistic formulation should prove helpful in the management of obesity and its related complications.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Obesity Agents / therapeutic use*
  • Cellulose / therapeutic use*
  • Cissus* / chemistry
  • Dietary Fiber / therapeutic use*
  • Double-Blind Method
  • Drug Synergism
  • Female
  • Humans
  • Male
  • Obesity / drug therapy*
  • Phytotherapy
  • Placebos
  • Plant Extracts / therapeutic use
  • Weight Loss / drug effects*

Substances

  • Anti-Obesity Agents
  • Dietary Fiber
  • Placebos
  • Plant Extracts
  • dikanut
  • Cellulose