Old and new questions about cholinesterases

Chem Biol Interact. 2008 Sep 25;175(1-3):30-44. doi: 10.1016/j.cbi.2008.04.039. Epub 2008 May 4.


Cholinesterases have been intensively studied for a long time, but still offer many fascinating and fundamental questions regarding their evolution, activity, biosynthesis, folding, post-translational modifications, association with structural proteins (ColQ, PRiMA and maybe others), export or degradation. They constitute an excellent model to study these processes, particularly because of the sensitivity and specificity of enzymic assays. In addition, a number of provocative ideas concerning their proposed non-conventional, or non-catalytic functions deserve to be further documented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • Biocatalysis
  • Cell Adhesion
  • Cell Differentiation
  • Cholinesterases* / biosynthesis
  • Cholinesterases* / chemistry
  • Cholinesterases* / genetics
  • Cholinesterases* / metabolism
  • Evolution, Molecular
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Molecular Sequence Data
  • Oxidative Stress


  • Cholinesterases