Preliminary study of buprenorphine and bupropion for opioid-dependent smokers

Am J Addict. Jul-Aug 2008;17(4):287-92. doi: 10.1080/10550490802138814.

Abstract

In this double-blind, placebo-controlled trial, bupropion (BUPRO, 300 mg/day) was compared to placebo (PBO) for the concurrent treatment of opioid and tobacco addiction in 40 opioid-dependent smokers stabilized on buprenorphine (BUPRE, 24 mg/day). Participants received contingent, monetary reinforcement for abstinence from smoking, illicit opioids, and cocaine. Significant differences in treatment retention were observed (BUPRE+BUPRO, 58%; BUPRE+PBO, 90%). BUPRO treatment was not more effective than placebo for abstinence from tobacco, opioids, or cocaine in BUPRE-stabilized patients. These preliminary findings do not support the efficacy of BUPRO, in combination with BUPRE, for the concurrent treatment of opioid and tobacco addiction.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / adverse effects
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Buprenorphine / adverse effects
  • Buprenorphine / therapeutic use*
  • Bupropion / adverse effects
  • Bupropion / therapeutic use*
  • Cocaine-Related Disorders / epidemiology
  • Cocaine-Related Disorders / rehabilitation*
  • Combined Modality Therapy
  • Comorbidity
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motivation
  • Narcotic Antagonists / adverse effects
  • Narcotic Antagonists / therapeutic use*
  • Opioid-Related Disorders / epidemiology
  • Opioid-Related Disorders / rehabilitation*
  • Smoking / epidemiology
  • Smoking Cessation*
  • Smoking Prevention
  • Token Economy

Substances

  • Antidepressive Agents, Second-Generation
  • Delayed-Action Preparations
  • Narcotic Antagonists
  • Bupropion
  • Buprenorphine