Control of massive bleeding in dengue hemorrhagic fever with severe thrombocytopenia by use of intravenous anti-D globulin

Pediatr Blood Cancer. 2008 Dec;51(6):812-3. doi: 10.1002/pbc.21708.


Dengue hemorrhagic fever (DHF) is a potentially lethal complication of mosquito borne viral disease, Dengue Fever. Thrombocytopenia is a constant finding in DHF/Dengue Shock Syndrome (DSS). We report two cases that fulfilled the WHO criteria of DSS: high fever, positive tourniquet test, severe thrombocytopenia (<10,000/mm(3)), hemo-concentration (Hematocrit increase >20%), hypotension and bleeding refractory to routine therapeutic measures, who showed dramatic improvement after receiving Intravenous Anti-D globulin (IV anti-D).

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child, Preschool
  • Female
  • Gastrointestinal Hemorrhage / drug therapy*
  • Gastrointestinal Hemorrhage / etiology
  • Hemorrhage / drug therapy*
  • Hemorrhage / etiology
  • Humans
  • Immunologic Factors / therapeutic use*
  • Lung Diseases / drug therapy*
  • Lung Diseases / etiology
  • Male
  • Rho(D) Immune Globulin / therapeutic use*
  • Severe Dengue / complications*
  • Thrombocytopenia / complications*


  • Immunologic Factors
  • Rho(D) Immune Globulin