Persistent dystonia induced by fluoxetine

Intern Med J. 2008 Aug;38(8):672-4. doi: 10.1111/j.1445-5994.2008.01747.x.


Serotonin-selective re-uptake inhibitors are prescribed widely because they are regarded as having less severe side-effects compared with tricyclics and monoamine oxidase inhibitors. With this popularity, increasing attention has been drawn to their adverse effects. Development of extrapyramidal symptoms has been reported in some patients while taking fluoxetine, a commonly used serotonin-selective re-uptake inhibitor. Here, we report a case of persistent dystonia, thought to be associated with short-term fluoxetine use, which required treatment with botulinum toxin type A.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Botulinum Toxins, Type A / therapeutic use
  • Dystonia / chemically induced*
  • Dystonia / diagnosis*
  • Dystonia / drug therapy
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Humans
  • Male
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use


  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Botulinum Toxins, Type A