Human mitochondrial variants influence on oxygen consumption

Mitochondrion. 2009 Feb;9(1):27-30. doi: 10.1016/j.mito.2008.10.002. Epub 2008 Oct 15.


This work investigates if human mitochondrial variants influence on maximal oxygen consumption (VO(2max)). With this purpose we recruited, as a uniform population in term of nutritional habits and life style, 114 healthy male Spanish subjects that practiced fitness exercises 3-4 times a week. Once mtDNA haplogroups were determined, we found that J presents with lower VO(2max) (P=0.02) than nonJ variants. J has been related with a lower efficiency of electron transport chain (ETC), diminished ATP and ROS production. Thus, the difficult to compensate the mitochondrial energetic deficiency could explain the accumulation of J haplogroup in LHON and multiple sclerosis. Furthermore, the lower ROS production associated to J could also account for the accrual of this variant in elderly people consequent to a decreased oxidative damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Adult
  • DNA / metabolism
  • DNA, Mitochondrial / metabolism
  • Electron Transport
  • Exercise
  • Exercise Test
  • Haplotypes
  • Humans
  • Male
  • Mitochondria / metabolism*
  • Mitochondria, Muscle / metabolism
  • Oxidative Stress
  • Oxygen Consumption*


  • DNA, Mitochondrial
  • Adenosine Triphosphate
  • DNA