Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet

J Ethnopharmacol. 2009 Jan 12;121(1):54-60. doi: 10.1016/j.jep.2008.09.029. Epub 2008 Oct 8.


Aim of the study: To evaluate the protective effects of total flavonoids of Litsea Coreana leve (TFLC) on rat high fat diet-induced hepatic steatosis model.

Materials and methods: Rats were given either a high fat diet alone or the same diet plus TFLC for 4 weeks.

Results: TFLC improved liver histology with reduced serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as decreased the over accumulation lipids in serum and liver. TFLC increased serum levels of leptin and insulin, while decreased serum TNFalpha level in high fat diet fed rat. Furthermore, TFLC was found increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha) in high fat diet fed rat liver. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in high fat diet fed rat liver.

Conclusions: TFLC exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions, improving the adipocytokines release and increasing the expression of PPARalpha.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / metabolism
  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Aspartate Aminotransferases / metabolism
  • Dietary Fats / administration & dosage
  • Disease Models, Animal
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use
  • Fatty Liver / enzymology
  • Fatty Liver / etiology
  • Fatty Liver / prevention & control*
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use*
  • Insulin / blood
  • Leptin / blood
  • Litsea / chemistry*
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Malondialdehyde / metabolism
  • Phytotherapy*
  • Plant Leaves / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase / metabolism
  • Tumor Necrosis Factor-alpha / metabolism


  • Antioxidants
  • Dietary Fats
  • Drugs, Chinese Herbal
  • Flavonoids
  • Insulin
  • Leptin
  • Tumor Necrosis Factor-alpha
  • Malondialdehyde
  • Superoxide Dismutase
  • Aspartate Aminotransferases
  • Alanine Transaminase