The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients

Cardiovasc Drugs Ther. 2009 Apr;23(2):145-51. doi: 10.1007/s10557-008-6155-2. Epub 2008 Dec 4.

Abstract

Purpose: To evaluate the effect of adding tomato extract to the treatment regime of moderate hypertensives with uncontrolled blood pressure (BP) levels.

Methods: Fifty four subjects with moderate HT treated with one or two antihypertensive drugs were recruited and 50 entered two double blind cross-over treatment periods of 6 weeks each, with standardized tomato extract or identical placebo. Plasma concentrations of lycopene, nitrite and nitrate were measured and correlated with BP changes.

Results: There was a significant reduction of systolic BP after 6 weeks of tomato extract supplementation, from 145.8 +/- 8.7 to 132.2 +/- 8.6 mmHg (p < 0.001) and 140.4 +/- 13.3 to 128.7 +/- 10.4 mmHg (p < 0.001) in the two groups accordingly. Similarly, there was a decline in diastolic BP from 82.1 +/- 7.2 to 77.9 +/- 6.8 mmHg (p = 0.001) and from 80.1 +/- 7.9 to 74.2 +/- 8.5 mmHg (p = 0.001). There was no significant change in systolic and diastolic BP during the placebo period. Serum lycopene level increased from 0.11 +/- 0.09 at baseline, to 0.30 +/- 01.3 micromol/L after tomato extract therapy (p < 0.001). There was a significant correlation between systolic BP and lycopene levels (r = -0.49, p < 0.001).

Conclusions: Tomato extract when added to patients treated with low doses of ACE inhibition, calcium channel blockers or their combination with low dose diuretics, had a clinically significant effect-reduction of BP by more than 10 mmHg systolic and more than 5 mmHg diastolic pressure. No side-effects to treatment were recorded and the compliance with treatment was high. The significant correlation between systolic blood pressure values and level of lycopene suggest the possibility of cause-effect relationships.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / isolation & purification
  • Antihypertensive Agents / therapeutic use*
  • Antioxidants / adverse effects
  • Antioxidants / isolation & purification
  • Antioxidants / therapeutic use*
  • Blood Pressure / drug effects
  • Carotenoids / blood
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Lycopene
  • Lycopersicon esculentum / chemistry*
  • Male
  • Middle Aged
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use

Substances

  • Antihypertensive Agents
  • Antioxidants
  • Plant Extracts
  • Carotenoids
  • Lycopene