Tissue analysis with high-resolution imaging mass spectrometry

A F Maarten Altelaar; Ron M A Heeren

doi:10.1007/978-1-59745-493-3_18

Tissue analysis with high-resolution imaging mass spectrometry

Methods Mol Biol. 2009:492:295-308. doi: 10.1007/978-1-59745-493-3_18.

Authors

A F Maarten Altelaar¹, Ron M A Heeren

Affiliation

¹ FOM Institute for Atomic and Molecular Physics FOM-AMOLF, Amsterdam, The Netherlands.

PMID: 19241041
DOI: 10.1007/978-1-59745-493-3_18

Abstract

Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers. Speed, resolution, sensitivity, and sample preparation protocols are no longer limiting factors in its application.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analytic Sample Preparation Methods
Animals
Brain / cytology*
Mass Spectrometry / methods*
Principal Component Analysis
Rats
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization