Tissue analysis with high-resolution imaging mass spectrometry

Methods Mol Biol. 2009:492:295-308. doi: 10.1007/978-1-59745-493-3_18.


Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers. Speed, resolution, sensitivity, and sample preparation protocols are no longer limiting factors in its application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analytic Sample Preparation Methods
  • Animals
  • Brain / cytology*
  • Mass Spectrometry / methods*
  • Principal Component Analysis
  • Rats
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization