The therapeutic potential of novel cannabinoid receptors

Pharmacol Ther. 2009 May;122(2):83-96. doi: 10.1016/j.pharmthera.2009.01.005. Epub 2009 Feb 25.

Abstract

Cannabinoids produce a plethora of biological effects, including the modulation of neuronal activity through the activation of CB(1) receptors and of immune responses through the activation of CB(2) receptors. The selective targeting of either of these two receptor subtypes has clear therapeutic value. Recent evidence indicates that some of the cannabinomimetic effects previously thought to be produced through CB(1) and/or CB(2) receptors, be they on neuronal activity, on the vasculature tone or immune responses, still persist despite the pharmacological blockade or genetic ablation of CB(1) and/or CB(2) receptors. This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cannabinoid Receptor Agonists*
  • Cannabinoid Receptor Antagonists*
  • Cannabinoid Receptor Modulators / metabolism
  • Cannabinoid Receptor Modulators / pharmacology
  • Cannabinoid Receptor Modulators / therapeutic use
  • Cannabinoids / chemistry
  • Cannabinoids / pharmacology
  • Cannabinoids / therapeutic use
  • Humans
  • Mice
  • Receptor, Cannabinoid, CB1 / agonists
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors
  • Receptor, Cannabinoid, CB2 / agonists
  • Receptor, Cannabinoid, CB2 / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / physiology
  • Receptors, Lysosphingolipid / physiology

Substances

  • Cannabinoid Receptor Agonists
  • Cannabinoid Receptor Antagonists
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • GPR55 protein, human
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB2
  • Receptors, G-Protein-Coupled
  • Receptors, Lysosphingolipid