Bronchial granular-cell tumor. Report of a case with preoperative cytologic diagnosis on bronchial brushings and immunohistochemical studies

Acta Cytol. 1991 Jul-Aug;35(4):375-80.


A 42-year-old man presented with a polypoid endobronchial mass of the right apical segmental bronchus. Bronchial brushing smears contained clusters of cells exhibiting abundant diffusely granular cytoplasm with indistinct borders. A cytologic diagnosis of granular-cell tumor was rendered. Histologic examination of the upper right lobectomy specimen provided confirmation. Immunohistochemically, the granular cells strongly reacted with the S-100 protein antibody. This case demonstrates that the cytologic diagnosis of bronchial granular-cell tumor is possible if this lesion is considered in the differential diagnosis of lung tumors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bronchi / pathology*
  • Cell Nucleus / ultrastructure
  • Cytodiagnosis / methods
  • Cytoplasmic Granules / ultrastructure
  • Granular Cell Tumor / pathology*
  • Granular Cell Tumor / surgery
  • Humans
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / surgery
  • Male