Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax

Georgian Med News. 2009 Mar:(168):104-7.


Research goal was study of separate and joint influence of bioregulator prostamax and Cu(II) and Cd(II) ions on the chromatin structure in situ. The thermal characteristics of the denaturation process of blood lymphocytes culture of aging people in the presence of some microg quantities of Cu(II) and Cd(II) ions have been determined. It has been shown that Cu(II) and Cd(II) ions at these low concentrations don't influence on the temperature stability of membrane, nuclear and cytoplasm proteins. It has been shown that Cu(II) ions cause an additional condensation of the heterochromatin, and Cd(II) ions cause decondensation of heterochromatin and its partial denaturation.

MeSH terms

  • Aged
  • Cadmium / blood*
  • Calorimetry, Differential Scanning / methods*
  • Copper / blood*
  • Heterochromatin / metabolism*
  • Humans
  • Lymphocytes / metabolism*
  • Nucleic Acid Denaturation / drug effects
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*


  • Heterochromatin
  • Oligopeptides
  • Prostamax
  • Cadmium
  • Copper