Impact of polycystic ovary syndrome on selected indicators of in vitro fertilization and intracytoplasmic sperm injection treatment success

J Womens Health (Larchmt). 2009 May;18(5):717-23. doi: 10.1089/jwh.2008.1149.


Objectives: To examine the effect of polycystic ovary syndrome (PCOS), a marker of the metabolic syndrome, on selected indicators of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment success.

Methods: A retrospective cohort study was conducted using existing data on 69 IVF/ICSI treatment cycles undergone by PCOS women and a caliper-matched sample of 69 IVF/ICSI treatment cycles undergone by non-PCOS women over a 7-year period at a major fertility treatment center. Matching criteria were age and date at IVF/ICSI treatment initiation. Process and outcome measures were used to define successful IVF/ICSI treatment. Statistical significance was determined at an alpha level of 0.05.

Results: The total number of oocytes and the number of immature oocytes retrieved in the process of an IVF/ICSI cycle were significantly higher in the context of PCOS. No significant differences were observed among PCOS and non-PCOS groups on various IVF/ICSI cycle outcomes, including high-grade embryo, pregnancy achievement, miscarriage, and live birth status.

Conclusions: Although IVF/ICSI yields more oocytes in the context of PCOS, IVF/ICSI outcomes do not differ significantly by PCOS status. Prospective cohort studies are needed to examine short-term and long-term health effects of PCOS in the context of IVF/ICSI.

MeSH terms

  • Adult
  • Cohort Studies
  • Comorbidity
  • Embryo Transfer / statistics & numerical data*
  • Female
  • Humans
  • Infertility, Female / epidemiology*
  • Infertility, Female / therapy
  • Polycystic Ovary Syndrome / epidemiology*
  • Polycystic Ovary Syndrome / therapy
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Retrospective Studies
  • Sperm Injections, Intracytoplasmic / statistics & numerical data*
  • Women's Health
  • Young Adult