The chronic oral administration of arginine aspartate decreases secretion of IGF-1 and IGFBP-3 in healthy volunteers

Fundam Clin Pharmacol. 2009 Jun;23(3):339-44. doi: 10.1111/j.1472-8206.2009.00716.x.


To investigate the effect of chronic oral arginine aspartate on the growth hormone (GH), GH-releasing hormone (GHRH), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) secretions in healthy volunteers. Twenty-three healthy non-athlete volunteer males were administered arginine aspartate (30 g) orally once daily at 21:00 h for 21 consecutive days. Subjects were hospitalized on days 0, 1, 3, 5, 7, 14 and 21 of treatment. At each hospitalization, concentrations of GHRH, GH, IGF-1 and IGFBP-3 were measured over 4 h after arginine aspartate intake. GH, IGF-1 and IGFBP-3 concentrations were also determined over 12 h at days 0, 1 and 21. Compared with day 1, 4 h GH levels dropped at day 5 and subsequently rose to levels not significantly different from initial ones. The latter was substantiated by 12 h GH levels that did not significantly change from days 1 to 21. GHRH levels were not statistically different, although there was a trend in median values that seemed to inversely mirror those of GH. This dynamic over the course of the study for GH and GHRH was accompanied by a general decrease in IGF-1 and IGFBP-3. In healthy volunteers, a chronic oral treatment with 30 g/day arginine aspartate is followed by a decrease in IGF-1 and IGFBP-3 secretions.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Arginine / administration & dosage
  • Arginine / pharmacology*
  • Aspartic Acid / administration & dosage
  • Aspartic Acid / pharmacology*
  • Drug Administration Schedule
  • Growth Hormone / drug effects
  • Growth Hormone / metabolism
  • Growth Hormone-Releasing Hormone / drug effects
  • Growth Hormone-Releasing Hormone / metabolism
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / drug effects*
  • Insulin-Like Growth Factor Binding Protein 3 / metabolism
  • Insulin-Like Growth Factor I / drug effects*
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Time Factors
  • Young Adult


  • Insulin-Like Growth Factor Binding Protein 3
  • Aspartic Acid
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Growth Hormone-Releasing Hormone
  • Arginine
  • arginine aspartate