Helicobacter pylori infection and dermatologic diseases

Eur J Dermatol. 2009 Sep-Oct;19(5):431-44. doi: 10.1684/ejd.2009.0739. Epub 2009 Jun 15.


Recent evidence suggests that Helicobacter pylori infections play a role in the pathogenesis of a variety of skin diseases. The best evidence for such a link is found for two diseases: chronic urticaria and immune thrombocytopenic purpura. Other diseases that have a purported, but not yet proven link to H. pylori are: cutaneous pruritus, Behçet's disease, nodular prurigo and lichen planus. Based on the current evidence for a relationship between H. pylori and chronic idiopathic thrombocytopenic purpura the European Helicobacter Study Group consensus 2007 recommended the eradication of Helicobacter pylori infection in affected patients. Lastly, single or few case reports have documented associations between Helicobacter pylori infection and rosacea, aphthous stomatitis, atopic dermatitis, alopecia areata, Schoenlein-Henoch purpura and Sjögren syndrome, but these are only descriptive in nature. Systematic studies examining the relationship between dermatologic entities and infection with H. pylori and documentation of the effect of H. pylori eradication are needed to further our understanding on this topic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease
  • Helicobacter Infections / complications*
  • Helicobacter pylori*
  • Humans
  • Psoriasis / etiology
  • Purpura, Thrombocytopenic, Idiopathic / etiology
  • Rosacea / etiology
  • Scleroderma, Systemic / etiology
  • Sjogren's Syndrome / etiology
  • Skin Diseases / etiology*
  • Stomach Diseases / complications
  • Urticaria / etiology