Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial

Homeopathy. 2009 Jul;98(3):137-41. doi: 10.1016/j.homp.2009.05.006.


Objective: The objectives of this study were to clinically determine the efficacy of individualised homeopathy in the treatment of minor recurrent aphthous ulceration (MiRAU).

Design & intervention: A randomized, single blind, placebo-controlled clinical trial of individualised homeopathy. One hundred patients with minor aphthous ulcer were treated with individualised homeopathic medicines or placebo and followed up for 6 days. Patients received two doses of individualised homeopathic medicines in the 6C potency as oral liquid at baseline and 12 h later. Pain intensity and ulcer size were recorded at baseline during and at the end of the trial (mornings of days 4 and 6).

Result: All 100 patients completed treatment. Between group differences for pain intensity and ulcer size were statistically significant at day 4 and at day 6 (P<0.05). No adverse effects were reported.

Conclusion: The results suggest that homeopathic treatment is an effective and safe method in the treatment of MiRAU.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Female
  • Homeopathy / methods*
  • Humans
  • Male
  • Middle Aged
  • Pain / drug therapy*
  • Pain / etiology
  • Phytotherapy / methods*
  • Single-Blind Method
  • Stomatitis, Aphthous / complications
  • Stomatitis, Aphthous / drug therapy*
  • Treatment Outcome