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, 52 (3), 483-97

Antidepressant Medication Use During Breastfeeding


Antidepressant Medication Use During Breastfeeding

Teresa Lanza di Scalea et al. Clin Obstet Gynecol.


We performed an electronic search by using MEDLINE, PreMEDLINE, Current Contents, Biological Abstracts, and PsycINFO from June 2002 to December 2008 using the following terms: "antidepressant drugs", "antidepressive agents", "human milk", "lactation", and "breastfeeding" and the generic name of each antidepressant. Articles in the English language with reports of antidepressants in maternal serum or breast milk, infant serum, and short-term and long-term clinical outcomes in the infants were obtained. The search yielded a total of 31 empirical papers. Breastfeeding and antidepressant treatments are not mutually exclusive. Sertraline, paroxetine, nortriptyline, and imipramine are the most evidence-based medications for use during breastfeeding.


Figure 1
Figure 1. Decision Making for Postpartum Depression Treatment
Source: Adapted from: Wisner et al. (2002) (58), Sit and Wisner (2006) (46) Abbreviations: PPD= postpartum depression; IPT= interpersonal psychotherapy; CBT= cognitive-behavioral psychotherapy; AD= antidepressant

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