Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides

J Bacteriol. 2009 Nov;191(21):6769-72. doi: 10.1128/JB.00431-09. Epub 2009 Aug 28.

Abstract

We report on the identification of a glycosyltransferase (GT) from Mycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo-inositol mannosides.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Bacterial / physiology
  • Gene Expression Regulation, Enzymologic / physiology
  • Glycosyltransferases / metabolism*
  • Lipopolysaccharides / biosynthesis
  • Mannosides / biosynthesis
  • Multigene Family
  • Mutation
  • Mycobacterium tuberculosis / enzymology*
  • Mycobacterium tuberculosis / ultrastructure

Substances

  • Bacterial Proteins
  • Lipopolysaccharides
  • Mannosides
  • lipoarabinomannan
  • lipomannan
  • Glycosyltransferases