Reducing the mystery of neuronal differentiation

Cell. 2009 Sep 18;138(6):1062-4. doi: 10.1016/j.cell.2009.09.001.


In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Neurogenesis
  • Neurons / cytology*
  • Peroxiredoxins / metabolism
  • Phosphoric Diester Hydrolases / metabolism
  • Spinal Cord / cytology*
  • Spinal Cord / embryology


  • Peroxiredoxins
  • Phosphoric Diester Hydrolases
  • glycerophosphodiester phosphodiesterase