[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion]

Zhong Yao Cai. 2009 May;32(5):740-4.
[Article in Chinese]


Objective: To investigate the effects of flavonoids from the leaves of Diospyros kaki L (FLDK) on the adhesion between the lymphocyte and the neurone.

Methods: Centrifugal assay for fluorescence-bsaed cell adhesion was used to assay the adhesion between the lymphocyte and the dorsal root ganglion (DRG).

Results: The adhesion was significantly suppressed in the presence of FLDK dose-dependently at 5, 25 microg/mL concentration. FLDK was also effective to inhibit the adhesion under the challenge of ICAM-1 by 28.5% and 50.1%, respectively. Furthermore, FLDK enforced the inhibition of anti-NCAM antibody on the lymphocyte adhesion to DRG cells.

Conclusion: FLDK might contribute to the prevention and treatment of the inflammation injury under neuron insult such as ischemia/reperfusion, neurotrauma and other neurodegenerative disease by inhibiting the adhesion between lymphocytes and neurons.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion / drug effects*
  • Diospyros / chemistry*
  • Dose-Response Relationship, Drug
  • Flavonoids / administration & dosage
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Ganglia, Spinal / cytology*
  • Ganglia, Spinal / drug effects
  • Intercellular Adhesion Molecule-1 / drug effects
  • Lymphocytes / cytology*
  • Lymphocytes / drug effects
  • Male
  • Neural Cell Adhesion Molecules / drug effects
  • Neurons / cytology
  • Neurons / drug effects
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Rats
  • Rats, Wistar


  • Flavonoids
  • Neural Cell Adhesion Molecules
  • Protective Agents
  • Intercellular Adhesion Molecule-1