Solitary fibrous tumor

J Clin Neurosci. 2009 Dec;16(12):1578-81. doi: 10.1016/j.jocn.2009.02.039. Epub 2009 Sep 29.


Intracranial solitary fibrous tumors (SFT) are typically dural based, CD34-positive neoplasms of mesenchymal origin. Since they were first described in 1996 at the meninges, fewer than 100 SFT had been reported in both cranial and spinal compartments of the central nervous system. SFT can resemble other spindle cell tumors both radiologically and histopathologically, and differentiation can be best achieved through viewing their ultrastructure and using immunohistochemical techniques. In this report, we present four patients with SFT. Upon diagnosing two patients with SFT located in the cerebellopontine angle and parasagittal areas, we reviewed our pathological files and found two more patients; one having a parasagittal tumor and the other having a convexity tumor, that had been diagnosed with hemangiopericytoma. These tumours proved to be SFT after an immunohistochemical re-examination.

MeSH terms

  • 12E7 Antigen
  • Adult
  • Antigens, CD / metabolism
  • Antigens, CD34 / metabolism
  • Cell Adhesion Molecules / metabolism
  • Cerebellum / pathology
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms* / metabolism
  • Meningeal Neoplasms* / pathology
  • Middle Aged
  • Pons / pathology
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Retrospective Studies
  • Solitary Fibrous Tumors* / metabolism
  • Solitary Fibrous Tumors* / pathology
  • Vimentin / metabolism


  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD34
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Proto-Oncogene Proteins c-bcl-2
  • Vimentin