A neurotrophic rationale for the therapy of neurodegenerative disorders

Curr Alzheimer Res. 2009 Oct;6(5):419-23. doi: 10.2174/156720509789207912.


The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimer's Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Cognition Disorders / drug therapy*
  • Glaucoma / drug therapy*
  • Humans
  • Nerve Growth Factors / therapeutic use*
  • Optic Nerve Injuries / drug therapy*
  • Receptors, Nerve Growth Factor / therapeutic use


  • Nerve Growth Factors
  • Receptors, Nerve Growth Factor