Novel one-pot three component reaction for the synthesis of [2-(alkylsulfanyl)imidazo[1,2-a]pyridin-3-yl](aryl)methanone

J Comb Chem. 2010 Jan-Feb;12(1):41-4. doi: 10.1021/cc900103r.


A one-pot, three-component reaction between pyridine, phenacyl bromide, and thiocyanate is described. The reaction afforded the corresponding special type of fully substituted imidazo[1,2-a]pyridine derivatives in good yields without using any catalyst or activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemical synthesis*
  • Bromides / chemistry
  • Combinatorial Chemistry Techniques*
  • Molecular Structure
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry


  • Acetophenones
  • Bromides
  • Pyridines
  • imidazo(1,2-a)pyridine