Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acids

J Am Chem Soc. 2010 Jan 20;132(2):460-1. doi: 10.1021/ja909571z.

Abstract

Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acid substrates has been achieved through the use of monoprotected chiral amino acid ligands. The absolute configuration of the resulting olefinated products is consistent with that of a proposed C-H insertion intermediate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemical synthesis
  • Aldehydes / chemistry
  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Catalysis
  • Crystallography, X-Ray
  • Cyclization
  • Diphenylacetic Acids / chemistry*
  • Lactones / chemical synthesis
  • Lactones / chemistry
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Aldehydes
  • Alkenes
  • Diphenylacetic Acids
  • Lactones
  • Organometallic Compounds
  • Palladium