Tissue engineering of skin

Burns. 2010 Jun;36(4):450-60. doi: 10.1016/j.burns.2009.08.016. Epub 2009 Dec 22.


The engineering of skin substitutes and their application on human patients has become a reality. However, cell biologists, biochemists, technical engineers, and surgeons are still struggling with the generation of complex skin substitutes that can readily be transplanted in large quantities, possibly in only one surgical intervention and without significant scarring. Constructing a dermo-epidermal substitute that rapidly vascularizes, optimally supports a stratifying epidermal graft on a biodegradable matrix, and that can be conveniently handled by the surgeon, is now the ambitious goal. After all, this goal has to be reached coping with strict safety requirements and the harsh rules of the economic market.

Publication types

  • Review

MeSH terms

  • Cells, Cultured
  • Extracellular Matrix
  • Homeostasis
  • Humans
  • Skin / cytology
  • Skin, Artificial*
  • Tissue Engineering*