Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)

Eur J Clin Nutr. 2010 Apr;64(4):436-8. doi: 10.1038/ejcn.2009.159. Epub 2010 Jan 20.


Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3+/-2.8 kg/m(2)) received 0, 7, 15 or 24 g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2 h after consumption. A dose-response reduction in postprandial glycemia (P=0.002, r(2)=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60 min after high, 90 min after high and intermediate and at 120 min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Appetite / drug effects*
  • Area Under Curve
  • Blood Glucose / metabolism
  • Bread
  • Cardiovascular Diseases / prevention & control
  • Diabetes Mellitus, Type 2 / drug therapy
  • Dietary Carbohydrates / administration & dosage
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Hyperglycemia / drug therapy*
  • Male
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Preparations / pharmacology*
  • Plant Preparations / therapeutic use
  • Postprandial Period
  • Reference Values
  • Risk Factors
  • Salvia*
  • Satiation / drug effects*
  • Seeds*


  • Blood Glucose
  • Dietary Carbohydrates
  • Plant Extracts
  • Plant Preparations