Hair growth promoting effect of Zizyphus jujuba essential oil

Food Chem Toxicol. 2010 May;48(5):1350-4. doi: 10.1016/j.fct.2010.02.036. Epub 2010 Mar 3.


This study was undertaken to examine the efficacy of essential oil from seeds of Zizyphus jujuba for its potential role on hair growth by in vivo method. Essential oil was applied at different concentrations (0.1%, 1% and 10%) over the shaved skin onto the backs of BALB/c mice and monitored for 21 days. After 21 days, mice treated with 1% and 10% of oil produced a greater effect on the length of hair which were measured to be 9.96 and 10.02 mm, respectively, as compared to the control (8.94 mm). We measured the weight of hair/cm(2) area of dorsal skin and also evaluated hair thickness and hair follicles microscopically after plucking the hair immediately from the shaved area of mice and found the best results for 1% of essential oil-treated mice. From this study, it is concluded that Z. jujuba essential oil possesses hair growth promoting activity.

MeSH terms

  • Animals
  • Female
  • Hair / drug effects*
  • Hair / growth & development
  • Hair Follicle / drug effects
  • Hair Follicle / growth & development
  • Mice
  • Mice, Inbred BALB C
  • Oils, Volatile / pharmacology*
  • Plant Extracts / pharmacology
  • Plant Oils / pharmacology*
  • Seeds / chemistry
  • Skin / drug effects
  • Ziziphus / chemistry*


  • Oils, Volatile
  • Plant Extracts
  • Plant Oils