Variation of interstitial glucose measurements assessed by continuous glucose monitors in healthy, nondiabetic individuals

Diabetes Care. 2010 Jun;33(6):1297-9. doi: 10.2337/dc09-1971. Epub 2010 Mar 9.


Objective: To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals.

Research design and methods: Seventy-four healthy children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.

Results: Sensor glucose concentrations were 71-120 mg/dl for 91% of the day. Sensor values were <or=60 or >140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P < 0.001).

Conclusions: Glucose values <or=60 and >140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Glucose / analysis*
  • Blood Glucose Self-Monitoring*
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Monitoring, Ambulatory*
  • Young Adult


  • Blood Glucose