A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial

J Atten Disord. 2010 Nov;14(3):281-91. doi: 10.1177/1087054709356388. Epub 2010 Mar 12.


Objective: Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD.

Design: A randomized, double-blind, placebo-controlled trial.

Setting: University-affiliated tertiary medical center.

Participants: 120 children newly diagnosed with ADHD, meeting DSM-IV criteria.

Intervention: Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial.

Outcome measure: Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales.

Results: The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis.

Conclusions: The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Bacopa
  • Centella
  • Child
  • Double-Blind Method
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Male
  • Paeonia
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Spirulina
  • Treatment Outcome
  • Withania


  • Drugs, Chinese Herbal
  • Plant Extracts