Wilms Tumor Predisposition

In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2020.
[updated ].


Purpose: This GeneReview is intended to help clinicians determine if a genetic basis can be identified in an individual with Wilms tumor in order to provide families with natural history and recurrence risk information.

Goal 1: Briefly describe the clinical characteristics of Wilms tumor.

Goal 2: Review the mechanisms of predisposition to Wilms tumor.

Goal 3: Provide an evaluation strategy to:

Goal 4: Discuss genetic counseling issues including mode of inheritance, recurrence risk, and evaluation of relatives at risk based on the underlying genetic mechanism.

Goal 5: Discuss management (e.g., tumor screening) recommendations for individuals with a genetic predisposition to Wilms tumor.

Publication types

  • Review