Wilms Tumor Predisposition

Review
In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993.
[updated ].

Excerpt

The purpose of this GeneReview is to:

  1. 1

    Briefly describe the clinical characteristics of Wilms tumor;

  2. 2

    Review the mechanisms of predisposition to Wilms tumor;

  3. 3

    Provide an evaluation strategy to determine if a proband with Wilms tumor has a predisposition to Wilms tumor, identify the genetic or epigenetic mechanism for Wilms tumor, and determine risks for additional medical complications;

  4. 4

    Review management (e.g., tumor screening) recommendations for individuals with a genetic predisposition to Wilms tumor;

  5. 5

    Review genetic counseling issues including mode of inheritance, recurrence risk, and evaluation of relatives at risk based on the underlying genetic mechanism.

Publication types

  • Review