Amyotrophic Lateral Sclerosis Overview

Nailah Siddique; Teepu Siddique

Amyotrophic Lateral Sclerosis Overview

Review

In: GeneReviews^® [Internet]. Seattle (WA): University of Washington, Seattle; 1993.

2001 Mar 23 [updated 2023 Sep 28].

Authors

Nailah Siddique¹, Teepu Siddique²

Book Editors

Margaret P Adam, Jerry Feldman, Ghayda M Mirzaa, Roberta A Pagon, Stephanie E Wallace, Anne Amemiya

Affiliations

¹ Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois
² Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences;, Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

PMID: 20301623
Bookshelf ID: NBK1450

Excerpt

The purpose of this overview is to increase the awareness of clinicians regarding genetic causes of amyotrophic lateral sclerosis (ALS) and related genetic counseling issues.

The following are the goals of this overview.

Goal 1: Describe the clinical characteristics of ALS.

Goal 2: Review genetic causes of ALS.

Goal 3: Provide an evaluation strategy to identify the genetic cause of ALS in a proband (when possible).

Goal 4: Provide a high-level view of management of ALS.

Goal 5: Inform genetic counseling of family members of an individual with ALS.

Sections

Publication types

Review