The purpose of this overview is to increase the awareness of clinicians regarding genetic causes of amyotrophic lateral sclerosis (ALS) and related genetic counseling issues. The following are the goals of this overview:
Goal 1: Describe the clinical characteristics of ALS.
Goal 2: Review genetic causes of ALS.
Goal 3: Provide an evaluation strategy to identify the genetic cause of ALS in a proband (when possible).
Goal 4: Inform genetic counseling of family members of an individual with ALS.
Goal 5: Provide a high-level view of management of ALS.
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