An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol

J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8. doi: 10.1210/jc.2010-0482. Epub 2010 Jun 9.


Background: Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models.

Objective: The objective of the study was to investigate the effect of a Polygonum cuspidatum extract (PCE) containing resveratrol on oxidative and inflammatory stress in normal subjects.

Research design and methods: Two groups (10 each) of normal-weight healthy subjects were randomized to placebo or PCE containing 40 mg resveratrol daily for 6 wk. Fasting blood samples were obtained prior to and after treatment at 1, 3, and 6 wk. Mononuclear cells were prepared for reactive oxygen species generation, RNA isolation, nuclear extract, and total cell homogenate preparation. Indices of oxidative and inflammatory stress, suppressor of cytokine signaling-3, phosphotyrosine phosphatase-1B, jun-N-terminal kinase-1, and inhibitor of kappaB-kinase-beta were measured by RT-PCR and Western blotting.

Results: The extract induced a significant reduction in reactive oxygen species generation, the expression of p47(phox), intranuclear nuclear factor-kappaB binding, and the expression of jun-N-terminal kinase-1, inhibitor of kappaB-kinase-beta, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo.

Conclusions: The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • Fallopia japonica* / chemistry
  • Gene Expression Regulation / drug effects
  • Humans
  • Inflammation Mediators / blood
  • Inflammation Mediators / metabolism
  • Insulin / blood
  • Leptin / blood
  • Lipids / blood
  • Oxidative Stress / drug effects
  • Placebos
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Reactive Oxygen Species / antagonists & inhibitors*
  • Reactive Oxygen Species / metabolism
  • Resveratrol
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*


  • Anti-Inflammatory Agents
  • Antioxidants
  • Blood Glucose
  • Cytokines
  • Inflammation Mediators
  • Insulin
  • Leptin
  • Lipids
  • Placebos
  • Plant Extracts
  • Reactive Oxygen Species
  • Stilbenes
  • Resveratrol