[The schedule of intralesional papillomatosis treatment with cidofovir]

Otolaryngol Pol. 2010 Mar-Apr;64(2):98-102. doi: 10.1016/S0030-6657(10)70043-3.
[Article in Polish]


Introduction: Recurrent respiratory papillomatosis (RRP) is a rare disease in children and adults. It is characterized by proliferation of benign squamous cell papillomas within the respiratory-digestive tract, predominantly the larynx. Standard treatment consists of surgical excision of papillomata to maintain airway patency and voice quality. For last several years cidofovir is the most contemporary adjuvant anti-viral treatment for recurrent respiratory papillomatosis and its topical use is widely described.

Material and methods: Intralesional cidofovir therapy was given to 20 patients treated for laryngeal papillomas in the Department of Otolaryngology in Poznan between I-XII.2009. The character of the lesion differed: from one anatomical site and moderate growth to four or five localizations with heavy extension. The number of cidofovir injections per patient varied from one to six times and the volume of solution ranges from 1-12 ml. The cidofovir injections were combined with laser or mechanical excision of the lesions. In disperse papillomata the injections administered in particular anatomical sites in 4-6 weeks period. In massive lesions injections were repeated in the same anatomical site.

Results: Complete remission was observed in 3 out of 20 patients. 12 patients show remission in a place of cidofovir injection. In 4 patients during the 4 week observation new foci of papillomatosis occurred. In two patients hepatic toxic side effect were observed.

Conclusions: Intralesional cidofovir injection has been shown to be an effective an safe therapy for laryngeal papilloma and should be considered in those patients who experienced disease relapse.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / administration & dosage*
  • Child
  • Cidofovir
  • Combined Modality Therapy
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Laryngeal Neoplasms / drug therapy*
  • Laryngeal Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / surgery
  • Organophosphonates / administration & dosage*
  • Papilloma / drug therapy*
  • Papilloma / surgery
  • Poland
  • Respiratory Tract Neoplasms / drug therapy*
  • Respiratory Tract Neoplasms / surgery
  • Treatment Outcome
  • Young Adult


  • Antineoplastic Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir