Simple and efficient preparation of 2,5-disubstituted oxazoles via a metal-free-catalyzed cascade cyclization

Changfeng Wan; Linfeng Gao; Qiang Wang; Jintang Zhang; Zhiyong Wang

doi:10.1021/ol101596s

Simple and efficient preparation of 2,5-disubstituted oxazoles via a metal-free-catalyzed cascade cyclization

Org Lett. 2010 Sep 3;12(17):3902-5. doi: 10.1021/ol101596s.

Authors

Changfeng Wan¹, Linfeng Gao, Qiang Wang, Jintang Zhang, Zhiyong Wang

Affiliation

¹ Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China.

PMID: 20681600
DOI: 10.1021/ol101596s

Abstract

A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Catalysis
Cyclization
Iodine / chemistry*
Molecular Structure
Oxazoles / chemical synthesis*
Oxazoles / chemistry

Substances

Aldehydes
Oxazoles
Iodine