Simple and efficient preparation of 2,5-disubstituted oxazoles via a metal-free-catalyzed cascade cyclization

Org Lett. 2010 Sep 3;12(17):3902-5. doi: 10.1021/ol101596s.

Abstract

A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Cyclization
  • Iodine / chemistry*
  • Molecular Structure
  • Oxazoles / chemical synthesis*
  • Oxazoles / chemistry

Substances

  • Aldehydes
  • Oxazoles
  • Iodine