Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole

Am J Obstet Gynecol. 2010 Dec;203(6):531-9. doi: 10.1016/j.ajog.2010.06.073. Epub 2010 Aug 21.

Abstract

Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to management of hydatidiform mole, including evacuation, twin mole/normal fetus pregnancy, prophylactic chemotherapy, and follow-up.

Publication types

  • Review

MeSH terms

  • Abortion, Therapeutic / methods
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Choriocarcinoma / diagnosis
  • Choriocarcinoma / drug therapy
  • Choriocarcinoma / mortality
  • Choriocarcinoma / pathology
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Gestational Trophoblastic Disease / diagnosis
  • Gestational Trophoblastic Disease / drug therapy*
  • Gestational Trophoblastic Disease / mortality
  • Gestational Trophoblastic Disease / pathology*
  • Humans
  • Hydatidiform Mole / drug therapy
  • Hydatidiform Mole / pathology
  • Hysterectomy / methods
  • Pregnancy
  • Risk Assessment
  • Survival Rate
  • Treatment Outcome
  • Uterine Neoplasms / diagnosis
  • Uterine Neoplasms / mortality
  • Uterine Neoplasms / pathology*
  • Uterine Neoplasms / therapy