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Randomized Controlled Trial
. 2010 May;16(5):585-90.
doi: 10.1089/acm.2009.0226.

Effect of Cs-4 (Cordyceps Sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial

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Free PMC article
Randomized Controlled Trial

Effect of Cs-4 (Cordyceps Sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial

Steve Chen et al. J Altern Complement Med. .
Free PMC article

Abstract

Objective: The objective of this study was to examine the effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy elderly subjects.

Design: Twenty (20) healthy elderly (age 50-75 years) subjects were enrolled in this double-blind, placebo-controlled, prospective trial. The subjects were taking either Cs-4 333 mg or placebo capsules 3 times a day for 12 weeks.

Measurement: Subjects received baseline screening including physical examination and laboratory tests. Maximal incremental exercise testing was performed on a stationary cycle ergometer using breath-by-breath analysis at baseline and at the completion of the study.

Results: After receiving Cs-4 for 12 weeks, the metabolic threshold (above which lactate accumulates) increased by 10.5% from 0.83 +/- 0.06 to 0.93 +/- 0.08 L/min (p < 0.02) and the ventilatory threshold (above which unbuffered H(+) stimulates ventilation) increased by 8.5% from 1.25 +/- 0.11 to 1.36 +/- 0.15 L/min. Significant changes in metabolic or ventilatory threshold were not seen for the subjects in the placebo group after 12 weeks, and there were no changes in Vo(2) max in either group.

Conclusion: This pilot study suggests that supplementation with Cs-4 (Cordyceps sinensis) improves exercise performance and might contribute to wellness in healthy older subjects.

Figures

FIG. 1.
FIG. 1.
Effect of Cs-4® and placebo on the metabolic threshold (V̇02θ) above which lactate accumulates during incremental exercise. Panel (A) shows absolute changes in V̇o2θ expressed as levels of oxygen uptake in L/min. Panel (B) shows percentage changes from baseline. *Statistical significance p = 0.022.
FIG. 2.
FIG. 2.
Effect of Cs-4® and placebo on the ventilatory threshold (V̇Eθ) above which unbuffered hydrogen ion stimulates the carotid body during incremental exercise. Panel (A) shows absolute changes in V̇Eθ expressed as levels of oxygen uptake in L/min. Panel (B) shows percentage changes from baseline. *Statistical significance p = 0.031.

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