Protein structure modeling

Methods Mol Biol. 2010:673:63-72. doi: 10.1007/978-1-60761-842-3_5.


The tertiary structure of proteins can reveal information that is hard to detect in a linear sequence. Knowing the tertiary structure is valuable when generating hypothesis and interpreting data. Unfortunately, the gap between the number of known protein sequences and their associated structures is widening. One way to bridge this gap is to use computer-generated structure models of proteins. Here we present concepts and online resources that can be used to identify structural domains in proteins and to create structure models of those domains.

MeSH terms

  • Amino Acid Sequence
  • Computational Biology / methods*
  • Databases, Protein
  • Humans
  • Models, Molecular*
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Structural Homology, Protein


  • Proteins