Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice

Biotechnol J. 2010 Sep;5(9):961-9. doi: 10.1002/biot.201000215.


An ethanol extract of fucoxanthin-rich seaweed was examined for its effectiveness as a nutraceutical for body fat-lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi-purified high-fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin-rich seaweed ethanol extract (Fx-SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx-SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high-fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol-regulating enzyme were also lowered by Fx-SEE supplement. Concentrations of plasma high-density lipoprotein-cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx-SEE groups than in the high-fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx-SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption.

MeSH terms

  • Animals
  • Anti-Obesity Agents / pharmacology
  • Body Weight
  • Cholesterol / blood
  • Dietary Fats / administration & dosage
  • Dietary Fats / metabolism
  • Dietary Supplements
  • Lipid Metabolism*
  • Lipids / blood
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity / metabolism
  • Obesity / therapy
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Seaweed / metabolism*
  • Weight Gain
  • Xanthophylls / pharmacology*


  • Anti-Obesity Agents
  • Dietary Fats
  • Lipids
  • Plant Extracts
  • Xanthophylls
  • fucoxanthin
  • Cholesterol