A comprehensive molecular interaction map of the budding yeast cell cycle

Mol Syst Biol. 2010 Sep 21;6:415. doi: 10.1038/msb.2010.73.

Abstract

With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from ∼600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes--signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Motifs
  • Cell Cycle Proteins / metabolism
  • Cell Cycle*
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal
  • Models, Biological
  • Models, Statistical
  • Open Reading Frames
  • Saccharomycetales / genetics
  • Saccharomycetales / physiology*
  • Signal Transduction

Substances

  • Cell Cycle Proteins
  • Fungal Proteins